PSA is also used as a means of monitoring disease: Its main use is to monitor disease: if PSA > 40, there is a high chance that there is nodal or metastatic spread; if PSA > 100, there is almost certainly metastatic spread; Note that reference ranges may vary between laboratories. Reference: NICE (December 2021). Suspected cancer: recognition PSA levels are measured in nanograms per milliliter (ng/mL), and a normal range typically falls between 0 and 4 ng/mL. It's essential to keep in mind that various factors can influence PSA levels, and individual baselines may vary. Age, ethnicity, and health play roles in determining what is considered a normal PSA level for an individual. A PSA level that stays elevated suggests something is going on in the prostate and further tests are required to determine if it is cancer or something else. If your PSA level is over 3.0 ng/ml, your PSA test should be repeated within 1 to 3 months. This is because the PSA sometimes returns to normal levels. The guidelines provide a rough guide to normal PSA levels (ng/ml) by age group. Age less than 60 years ~ less than 3.0 ng/ml; Age 60-69 years ~ less than 4.0 ng/ml; Age 70-79 years ~ less than 5.0 ng/ml; Even if your PSA level is within the normal range, if your GP has any concerns you may be asked to have your PSA level checked again. Screening at 55-69 years. Survival rates. Summary. Prostate cancer is most prevalent in males over age 50 years. African American males and those with a family history of the disease may be at Background The optimal upper limit of the normal range for prostate-specific antigen (PSA) is unknown. Among the 2950 men (age range, 62 to 91 years), prostate cancer was diagnosed in 449 (15. The free PSA percentage is an aid in distinguishing prostate cancer from benign prostatic conditions in individuals with a prostate age 50 years and older with a total PSA between 3 and 10ng/mL and negative digital rectal examination findings. This approach allows assessment of age-specific PSA levels. For men younger than 50 years of age, PSA levels should be 0-2.5 ng/mL. For men 50-59 years of age, normal PSA levels are 0-3.5 ng/mL. For men 60-69 years of age, PSA should be 0-4.5 ng/mL. Prostate specific antigen clinical Case study 2 Peter was 63 years of age and divorced when diagnosed with prostate cancer. Serial monitoring over the previous 2 years revealed normal DRE but PSA increased from 4.1 ng/ mL to 4.9 ng/mL. Before diagnosis, his PSA had reached 5.8 ng/mL and DRE revealed a small nodular area in the left lobe. Peter Prostate-specific antigen (PSA) is a serine protease (~30kDa) secreted almost exclusively by prostate epithelial cells. including the use of age-adjusted PSA reference ranges, PSA density, PSA velocity, and free-to-total PSA ratio. Clinical Significance. and suggests that there is no "normal" reference range for PSA. The detection PCKQT.